Hypoandrogenism as a manifestation of comorbid pathology in the violation of natural fertility of women of reproductive age

Objective — optimization of pre‑gravid preparation patients with hypoandrogenism and history early pregnancy losses.
 Materials methods. Examinations at the pre‑pregnant stage involved 69 women a loss (group I). The control group consisted 30 healthy II). Hormonal examination was performed in first phase menstrual cycle (5 7 days) using Vitros automated system Jonson & company, biochemical on Hitachi 912 analyzer standard Roche (Switzerland) kits.
 Results. For main group, signs functional hypogonadism violation ovarian steroidogenesis were characteristic following manifestations: decrease sex steroids’ level, which directly significantly correlated indicators gonadotropic hormones: luteinizing hormone (LH) estradiol r = 0.67; follicle‑stimulating (FSH) 0.64; LH dihydroepiandrosterone sulfate (DGEA‑C) 0.33 (p 0.02), FSH DGEA‑C 0.27 0.03). This showed dyslipidemia an increase cholesterol index compared to control: 5.43 [5.04; 5.82] versus 4.04 [3.87; 4.21]mmol/l < 0.05), tendency towards level low‑density lipoproteins 3.24 mmol/l [2.9; 3.59] and, respectively, 2.12 [1.93; 2.32] 0.15). There high‑density 1.42 [1.12; 1.71] 1st comparison indicator 2.30 [1.70; 2.89] 0.58). presence inverse significant relationships average strength between concentrations (r – 0.46; p 0.001), triglycerides –0.55; 0.0001), testosterone –0.44; 0.006) has been revealed.
 Conclusions. Women reproductive age hypoandrogynism losses have dyslipidemia. scheme such should include gastroenterologist’s consultation personalized therapy identified disorders for prevention dysmetabolic diseases onset pregnancy.